Asymptotic distributions of the signal-to-interference ratios of LMMSE detection in multiuser communications

Let ${\mathbf{s}}_k=\frac{1}{\sqrt{N}}(v_{1k},...,v_{Nk})^T,$ $k=1,...,K$, where $\{v_{ik},i,k$ $=1,...\}$ are independent and identically distributed random variables with $Ev_{11}=0$ and $Ev_{11}^2=1$. Let ${\mathbf{S}}_k=({\mathbf{s}}_1,...,{\mathbf{s}}_{k-1},$ ${\mathbf{s}}_{k+1},...,{\mathbf{s}}_K)$, ${\mathbf{P}}_k=\operatorname {diag}(p_1,...,$ $p_{k-1},p_{k+1},...,p_K)$ and \beta_k=p_k{\mathbf{s}}_k^T({\mathb f{S}}_k{\mathbf{P}}_k{\mathbf{S}}_k^T+\sigma^2{\mathbf{I}})^{-1}{\math bf{s}}_k, where $p_k\geq 0$ and the $\beta_k$ is referred to as the signal-to-interference ratio (SIR) of user $k$ with linear minimum mean-square error (LMMSE) detection in wireless communications. The joint distribution of the SIRs for a finite number of users and the empirical distribution of all users' SIRs are both investigated in this paper when $K$ and $N$ tend to infinity with the limit of their ratio being positive constant. Moreover, the sum of the SIRs of all users, after subtracting a proper value, is shown to have a Gaussian limit.Comment: Published at http://dx.doi.org/10.1214/105051606000000718 in the Annals of Applied Probability (http://www.imstat.org/aap/) by the Institute of Mathematical Statistics (http://www.imstat.org

Systematic analysis of leucine-rich repeat disease resistance genes in maize

Leucine-rich repeat disease resistance (LRRDR) genes are important for defending plants from a range of pathogens. However, little information has been reported on the systematic analysis of LRRDR genes in maize. In this study, 235 LRRDR genes were identified in the complete genome sequence of maize (Zea mays cv. B73), classified as six different structural types, and then characterized based on conserved protein motifs, chromo- somal locations and gene duplications. Subsequent phylogenetic comparisons indicated that ~20 pairs of maize LRRDR proteins possessed high similarities to LRRDR proteins with known functions. Analyses of the physical locations and duplications of LRRDR genes indicated that gene duplication events involving LRRDR genes were high in maize and 84% occurred between chromosomes, which may ensure the functional performance and en- hancement of maize LRRDR genes. Meanwhile, the functions and expression patterns of the LRRDR genes were associated with their conserved protein secondary structures, suggesting that different conserved domains might distinguish their biological functions. Transcripts of 13 genes were regulated by two or more fungal pathogens, respectively, indicating that one LRRDR gene might mediate resistance to multiple fungal pathogens, suggest- ing that the signal networks of the maize-fungal pathogen interactions were partially crossed. Additionally, we screened five candidate LRRDR genes for ear rot resistance. The results reported in this study contribute to an improved understanding of the LRRDR gene family in maize

Nuclear GRP75 Binds Retinoic Acid Receptors to Promote Neuronal Differentiation of Neuroblastoma

Retinoic acid (RA) has been approved for the differentiation therapy of neuroblastoma (NB). Previous work revealed a correlation between glucose-regulated protein 75 (GRP75) and the RA-elicited neuronal differentiation of NB cells. The present study further demonstrated that GRP75 translocates into the nucleus and physically interacts with retinoid receptors (RARα and RXRα) to augment RA-elicited neuronal differentiation. GRP75 was required for RARα/RXRα-mediated transcriptional regulation and was shown to reduce the proteasome-mediated degradation of RARα/RXRαin a RA-dependent manner. More intriguingly, the level of GRP75/RARα/RXRα tripartite complexes was tightly associated with the RA-induced suppression of tumor growth in animals and the histological grade of differentiation in human NB tumors. The formation of GRP75/RARα/RXRα complexes was intimately correlated with a normal MYCN copy number of NB tumors, possibly implicating a favorable prognosis of NB tumors. The present findings reveal a novel function of nucleus-localized GRP75 in actively promoting neuronal differentiation, delineating the mode of action for the differentiation therapy of NB by RA

New Perspectives on Chinese Herbal Medicine (Zhong-Yao) Research and Development

Synthetic chemical drugs, while being efficacious in the clinical management of many diseases, are often associated with undesirable side effects in patients. It is now clear that the need of therapeutic intervention in many clinical conditions cannot be satisfactorily met by synthetic chemical drugs. Since the research and development of new chemical drugs remain time-consuming, capital-intensive and risky, much effort has been put in the search for alternative routes for drug discovery in China. This narrative review illustrates various approaches to the research and drug discovery in Chinese herbal medicine. Although this article focuses on Chinese traditional drugs, it is also conducive to the development of other traditional remedies and innovative drug discovery

A simulation study on the measurement of D0-D0bar mixing parameter y at BES-III

We established a method on measuring the \dzdzb mixing parameter $y$ for BESIII experiment at the BEPCII $e^+e^-$ collider. In this method, the doubly tagged $\psi(3770) \to D^0 \overline{D^0}$ events, with one $D$ decays to CP-eigenstates and the other $D$ decays semileptonically, are used to reconstruct the signals. Since this analysis requires good $e/\pi$ separation, a likelihood approach, which combines the $dE/dx$, time of flight and the electromagnetic shower detectors information, is used for particle identification. We estimate the sensitivity of the measurement of $y$ to be 0.007 based on a $20fb^{-1}$ fully simulated MC sample.Comment: 6 pages, 7 figure

Interplay of quantum magnetic and potential scattering around Zn or Ni impurity ions in superconducting cuprates

To describe the scattering of superconducting quasiparticles from non-magnetic (Zn) or magnetic (Ni) impurities in optimally doped high T$_c$ cuprates, we propose an effective Anderson model Hamiltonian of a localized electron hybridizing with $d_{x^2-y^2}$-wave BCS type superconducting quasiparticles with an attractive scalar potential at the impurity site. Due to the strong local antiferromagnetic couplings between the original Cu ions and their nearest neighbors, the localized electron in the Ni-doped materials is assumed to be on the impurity sites, while in the Zn-doped materials the localized electron is distributed over the four nearest neighbor sites of the impurities with a dominant $d_{x^2-y^2}$ symmetric form of the wave function. With Ni impurities, two resonant states are formed above the Fermi level in the local density of states at the impurity site, while for Zn impurities a sharp resonant peak below the Fermi level dominates in the local density of states at the Zn site, accompanied by a small and broad resonant state above the Fermi level mainly induced by the potential scattering. In both cases, there are no Kondo screening effects. The local density of states and their spatial distribution at the dominant resonant energy around the substituted impurities are calculated for both cases, and they are in good agreement with the experimental results of scanning tunneling microscopy in Bi$_2$Sr$_2$CaCu$_2$O$_{8+\delta}$ with Zn or Ni impurities, respectively.Comment: 24 pages, Revtex, 8 figures, submitted to Physical Review B for publication. Sub-ject Class: Superconductivity; Strongly Correlated Electron

Synthesis and Bio-Activity Evaluation of Scutellarein as a Potent Agent for the Therapy of Ischemic Cerebrovascular Disease

Scutellarein, the main metabolite of scutellarin in vivo, has relatively better solubility, bioavailability and bio-activity than scutellarin. However, it is very difficult to obtain scutellarein in nature compared with scutellarin. Therefore, the present study focused on establishing an efficient route for the synthesis of scutellarein by hydrolyzing scutellarin. The in vitro antioxidant activities of scutellarein were evaluated by measuring its scavenging capacities toward DPPH, ABTS+•, •OH free radicals and its protective effect on H2O2-induced cytotoxicity in PC12 cells using MTT assay method. The results showed that essential point to the synthesis was the implementation of H2SO4 in 90% ethanol in N2 atmosphere; scutellarein had stronger antioxidant activity than scutellarin. The results have laid the foundation for further research and the development of scutellarein as a promising candidate for ischemic cerebrovascular disease